Body weight bw, waist circumference wc, hormones, and proinflammatory markers were evaluated. Evaluation of acute and subacute toxicity of pinus. Adult female wistar rats n24 weighing between 182 to 186grams were randomly assigned into three groups a, b and c of n8 in each group. Wistar rat definition of wistar rat by medical dictionary. Bone and blood samples later the left kidney was removed. Effect of coenzyme q10 on depression paradigms in male wistar. The result of analysis of the effect of wood sponge filling on incision wound healing on female white rats rattus norvegicus l. Measurement of two new indicators of cardiac reserve in.
Effects of age and anesthetic on plasma glucose and insulin. This study was designed to investigate the biochemical, hormonal and histological changes in prostate of male wistar rats after 3 and 5months dm. Health, general science and technology, general albinism psychological aspects antidepressants depression mood disorder depression, mental enzymes. In the present study, using the same semiacute gavage model in wistar han rats, the potential impacts of cnf ingestion beyond direct toxicity, including effects on the fecal microbiome and metabolome, intestinal ileal epithelial cell mrna expression of genes involved in maintaining or regulating cell permeability, and ileal cytokine.
Histopathology of skin and kidney of rat neonates showed marked. It is suggested that greater responses of soleus muscle fibers of wistar hannover than wistar rats may be related to the different expression of protein, although the precise. Social contacts and production of 50khz short ultrasonic. We built a treadmill that used a 38 cm wide and 3 m long looped sheet of paper. Free pdf printer and other freeware create pdf documents from windows applications convert microsoft access databases to mysql. Focal middle cerebral artery ischemia in rats via a. Different responses in soleus muscle fibers of wistar and. Anticataractogenic effect of hesperidin in galactoseinduced cataractogenesis in wistar rats. Under sodium pentobarbital anesthesia 60 mgkg two branches of the period, blood and urine samples were taken and frozen renal artery of the right kidney were ligated and 2 weeks at 80c until analysis fig. The dominant lethal mutation test in male and female mice revealed that single oral doses of ketoconazole as high as 80 mgkg produced no mutation in any stage of germ cell development. Cryotherapy was applied immediately after injury immersion in water at 10c for 20minutes.
Comparison of the reacitons of male and female wistar rats. The same year that man landed on the moon, the first designs for a laser printer were developed by gary starkweather, at xeroxs research facility in new york. Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and wistar rats erika r. Feb 17, 2016 bone marrow suppression is the most significant toxicity associated with melphalan hydrochloride for injection in most patients. Create pdfs from almost any application free software. In addition, stevia compounds will be more easily mixed and analyses will be more easily developed when stevia is in drinking water than when it is in the diet.
Strontium causes osteomalacia in chronic renal failure rats. Its longevity and high rate of spontaneous tumours make it an ideal. Irvingia gabonensis leaves mitigate arsenicinduced renal toxicity in wistar rats. The effects of aerobic training on the il17 and ifn. Notably, it is a referred, highly indexed, online international journal with high impact factor. Chronic inhalation exposure of wistar rats and two different strains of mice to dieselengine exhaust, carbon black, and titanium dioxide. Here we report data from a study in rats demonstrating a causal role of sr in the development of osteomalacia in chronic renal failure. Rutin administration attenuates myocardial dysfunction in diabetic rats julliano f c guimaraes1, bruno p muzio1, camila m rosa1, andre f nascimento1, mario m sugizaki1, ana a h fernandes2, antonio c cicogna1, carlos r padovani1, marina p okoshi1 and katashi okoshi1,3 abstract.
Materials and methods investigation carried out at the dr. Each animal was anesthetized with 3% isoflurane in an induction chamber, which was maintained during the procedure with 2. Experimental pro tocols for this study were approved by the ethics com mittee of institute of physical education, chongqing university. Then, a series of dilute nacl solutions, ranging from 0. The fa gene was transferred from the zucker rat m strain to the wistar kyoto wky rat.
To develop a metabolic syndrome rat model by induction of fructose drinking water fdw in male wistar rats. Carbamazepine does not alter the intrinsic cardiac function. This manuscript has been reproduced from the microfilm master. Perinatal exposure to a glyphosatebased herbicide impairs. The gastrocnemius muscle was injured by mechanical crushing. A longterm feeding study in swiss albino mice and in wistar rats showed no evidence of oncogenic activity. The present research exploration is intended to inspect the chemotherapeutic potency of fisetin in 1,2. In there was a widespread practice of keeping rats as a domesticated pet during the edo period and in the 18th century guidebooks on keeping domestic rats were published by youso tamanokakehashi 1775 and chigan sodategusa 1787. Hepatotoxicity and ultra structural changes in wistar rats. The wistar rat is an outbred stock, used in all fields of medical and biological research.
Jun 07, 2018 carcinogenesis, mutagenesis, impairment of fertility. Comparative studies have also shown that several of these compounds taste sweet to some mammalian species but not to others bachmanov et al. Pdf experimentallyinduced hypertension in wistar rats. Wistar han list of studies wistar han rats species strain sex route vehicle chemical rats wistar han male and female gavage corn oil pentabromodiphenyl ether mixture de71 technical grade rats wistar han male and female gavage corn oil tetrabromobisphenol a rats wistar han male and female gavage water green tea extract rats wistar han. International journal of science and research ijsr is published as a monthly journal with 12 issues per year. The article has been removed from that issue because it will be included in an upcoming special section of the journal on pediatric drug disposition and pharmacokinetics. Effects of cryotherapy combined with therapeutic ultrasound. Pdf mobile phone usage and male infertility in wistar rats. Umi films the text directly from the original or copy submitted. Supports citrix, terminal server, windows server 2019 2016 2012 2008 2008r2 2003.
The age at detection of first glycosuria has varied from 48 to 120 days, with a mean of 67 days. At the same time, wistar animals with normal blood pressure were selected to be used as a samegeneticbackground normotensive control of the spontaneously hypertensive rats. Biomarker responses serum biochemistry in pregnant female. Starkweather is credited with creating the first fullyformed. There were no dietary factors identified to account for the high incidence of pancreatic proliferative lesions in the present bioassay.
The longevans rat is an outbred rat developed by drs. Vista do maternal and fetal toxicity of wistar rats exposed to. After arrival, the rats were placed individually in polypropylene cages with dustfree wood chips for 710 days before testing, and the cages were kept. Wistar and sd rats were assigned for 2 experimental groups for 17 weeks. The alkaline comet assay was conducted in wistar rats after oral acute exposure to mgo nps and mps at 24 h and 72 h sampling periods as per the method of tice et al. The protective effect of quercetin on diazinoninduced. One of the good model of obese rats is zucker rats. Pieces fit tight into one another and can be 360 degree rotated to form any tunnelshape you like. Comparison of the reacitons of male and female wistar rats to 5day exposure to 2g hypergravity. Forty male wistar rats aged 2021 weeks, weighing 200300 g, obtained from the animal house of the university of port harcourt, nigeria were used for all experiments.
The whole blood was withdrawn in edtacoated tubes from retroorbital plexus of rats. To investigate molecular mechanisms, gln or ala was given to wistar rats on a highfat diet hfd, and metabolic parameters, euglycemic hyperinsulinemic clamp with tracers, and western blot were done. The current study included 24 male rats, which were divided into 4 groups, each group included 6 rats. Biochemical, hormonal and histological changes in prostate of. Niaaa research monograph 6, us government printing office, washington dc 1981. Seventy male wistar rats were divided into five groups. Comparison of the reacitons of male and female wistar rats to. Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and wistar rats. Rats orally exposed to 1 25 % concentrations of each of the test leachates were examined for clinical signs of toxicity and body weight gain during exposure. Pdf effect of grape seed extract on lipid profile and. The survey, performed at the 10th generation of backcrossing, showed that wistar fatty rats fafa, a congenic strain of wky, developed obesity and obesityrelated features, such as hyperinsulinemia and hyperlipemia, in the same manner as zucker fatty rats.
Liver and kidney dysfunction in wistar rats exposed to. Genotoxicity definition of genotoxicity by medical dictionary. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. It is an albino strain, easytohandle, it is however slower learner than long evans rat. Wistar rats were exposed to a welldispersed toner mean of mmad. Leaves ethanol extracts prevented the increase of cortisol level and the decrease of estrogen level in female wistar rats rattusnorvegicus exposed to cell phone radiation.
Pdf cytogenetic effects of lambdacyhalothrin on wistar. The rats were obtained and maintained in the animal holdings of the department of anatomy, school of basic medical sciences, university of benin, benin city, nigeria. Therefore, the following tests should be performed at the start of therapy and prior to each subsequent dose of melphalan hydrochloride. We speculate that lesser negative effect of hdc compared to ldc on the preimplantation embryo development could be the consequence of the lesser norepinephrine levels andor elevated serotonin levels tab. The 20 mgkgbwt of dmh was injected to the investigational rats via subcutaneous route once in a week for 15 weeks to induce colon cancer in a rat model. Spontaneous acute lymphomas and related leukemias, occurring in three of 2,974 male wistar. Epidemiological studies suggest that between 70 and 80% of people developing epilepsy will go into remission, while the remaining patients continue to have. The amount of dermis collagen in the skin of wistar rats, if there is an increase is a sign of the protective effect of purple corn extract zea mays on collagen damage due to exposure to uvb rays and biomarkers of increased fibroblast production. Twentysix adult male wistar rats were assigned into three groups.
Body weights for all routesvehicles for wistar han rats. Voltar aos detalhes do artigo maternal and fetal toxicity of wistar rats exposed to herbicide metolachlor baixar baixar pdf. Acute sodium arseniteinduced hematological and biochemical. Wister synonyms, wister pronunciation, wister translation, english dictionary definition of wister. For this study, wistar rats n50, weight 37664 g were used for inducing 1 n35 or 2 n15 h of mcao. Rutin administration attenuates myocardial dysfunction in.
In 1960, okamoto at kyoto university selected wistar rats based on the expression of spontaneous hypertension. Evaluation of acute and subacute toxicity of pinus eldarica bark extract in wistar rats akram ghadirkhomi1, leila safaeian2, behzad zolfaghari3, mohammad reza agha ghazvini4, parisa rezaei5 1. This particular colony was selected because of a low incidence of hydronephrosis. Brain ethanol in aa, ana, and wistar rats monitored with oneminute. In the present study virgin wistar female rats served as experimental. View of toxicological evaluation and antiinflammatory effects of the.
Summary the spontaneously hypertensive rat shr initially bred in kyoto is the most widely studied animal model of essential hypertension. Mar 01, 2016 pdf the formatted version was erroneously included in the 2016 march issue with page numbers 366369. Pdf disseminated intravascular coagulation in wistar rats. Evaluation and antiinflammatory effects of the antiarthritic herbal formulations, jointeez and arthropower in albino wistar rats download download pdf. Biological variability in wistar kyoto rats implications for research with the spontaneously hypertensive rat theodore w. The quality of this reproduction is dependent upon the quality of the copy submitted. Group i received propylene glycol and group ii rats were given the eeac, 100. Effect of coenzyme q10 on depression paradigms in male wistar rats and swiss albino mice. Linkable tunnel piece for rats or other small pets. Spontaneous nonthymic t cell lymphomas in young wistar. A total of 36 female wistar rats total 6 groups, n 6 per group 6 8 weeks old, weighing 150 gm were used in the study.
Rats track odour trails accurately using a multilayered. Dosedependent effects of strontium on bone of chronic renal. Histological studies of the effects of monosodium glutamate. Differential effects of h2 receptor antagonists on male. Methods experimental design using the remnant kidney model, chronic renal failure was induced in 32 female wistar rats at eight weeks of age. We trained nine female wistar rats to track odour trails see methods. A new, spontaneously diabetic syndrome has been recognized in nonobese outbred wistar rats of both sexes. At the time of the experiment, their body weight was between 250 and 350 g. To share the full product catalog, please use the product catalog download option from the navigation bar at the top of the page. Correction to effect of age on the hepatocellularity number. Proliferative exocrine pancreatic lesions in aged wistar rats. Long evans rats are white with a black hood, or occasionally white with a brown hood.
The wistar institute is an independent, nonprofit research institution in biomedical science, with special expertise in oncology, immunology, infectious disease and vaccine research. The study was performed on 108 adult, male wistar rats from the charles river st. Are sprague dawley rats better than wistar rats for. Significant increase in ros and lipid peroxidation level with simultaneously decrease in sperm count, alterations in sperm tail morphology were observed in the exposed group. The lowest concentration at which there was a reliable difference in the preference scores of conditioned and control rats was defined as the detection threshold.
Correction to effect of age on the hepatocellularity number for wistar rats created date. Effect of coenzyme q10 on depression paradigms in male. Send low resolution image to level 2 postscript printer. Maternal and fetal toxicity of wistar rats exposed to. Groups a and b serve as treatment while c was the control. Blood, liver and kidney of surviving rats were examined for serum biochemical parameters, organ weight gain and histopathology. Just click print and select cutepdf writer as your printer. The establishment of metabolic syndrome model by induction. This study aimed to compare the hypolipidaemic activities of different monascus pigments yellow, red and orange pigments and elucidate their possible regulatory mechanisms on lipid and cholesterol metabolism in rats fed on a highfat diet hfd. Located in the university city section of philadelphia, wistar was founded in 1892 as americas first nonprofit institution solely focused on biomedical research and training. American writer known for his novel the virginian, often considered the first western. In an attempt to expedite the issue, 70 days old wistar rats n 6 were exposed to mobile phone radiofrequency rf radiation for 2 h per day.
Wister definition of wister by the free dictionary. On the other hand, the use of rats as lab animal bears low cost and greater availability than the use of chinchillas. The reduction in body weight gain of rats from groups exposed to 300 and mg kg. Cytogenetic effects of lambdacyhalothrin on wistar rat bone marrow. Nephroprotective effect of sonchus oleraceus extract. Association dangerous goods regulations manual iata. Pdf effects of age and anesthetic on plasma glucose and. Laboratory values see inside back cover for continuation. Fisetin suppresses 1,2dimethylhydrazineinduced colon. In conclusion, exposure to mobile phone radiations induces oxidative stress in male wistar rats which may lead to alteration in sperm parameters and affects their fertility. Long and evans in 1915 by crossing several wistar females with a wild gray male. Only the one with the hole has to be printed with support. To achieve this objective, al2o3 of three different sizes 30nm, 40nm and bulk was orally administered for 28 days to 9 groups of 10 wistar rats each, at the dose of 500, and 2000 mgkg rat.
Twenty male wistar rats were randomly assigned into four groups of five rats each. Its longevity and high rate of spontaneous tumours make it an ideal choice for ageing studies. The unloadingrelated reductions of muscle weight and fiber crosssectional area vs. Thirty four albino, male, wistar rats, weighing 250. Acute oral toxicity study of magnesium oxide nanoparticles. Disseminated intravascular coagulation in wistar rats article pdf available in american journal of pathology 43. The wistar rat, wistar hannover wistar han rat, and wistar unilever wu rat are outbred rat strains, while the wistar kyoto and wistar furth rats are inbred strains. The effect of physical exercise on ovarian follicles of. Animals were grouped into five n8, housed 12 hr lightdark cycle and given access to rodent chow and tap water ad libitum. Report by national journal of physiology, pharmacy and pharmacology. Monascus yellow, red and orange pigments from red yeast. Free pdf printer create pdf documents from windows applications. A tenth group of 10 rats received distilled water and served as control.
It can spread various types of zoonotic diseases, most commonly, rat fever caused by streptobacillus moniliformis, ring worm infestation, rabies, tetanus, and. Assessment of pulmonary toxicity induced by inhaled toner. Pdf effect of melatonin on carbon tetrachloride induced. Relationship between serotonin and norepinephrine levels and. A new genetically obesehyperglycemic rat wistar fatty. Efosa g ewere1,2, ngozi p okolie2, gerald i eze3, deborah a jegede1 1department of biochemistry, university of uyo, uyo, nigeria 2department of biochemistry, university of benin, benin, nigeria 3department of anatomy, university of benin, nigeria abstract arsenic has been reported to contaminate groundwater and. Effect of melatonin on carbon tetrachloride induced kidney injury in wistar rats. Epilepsy is the most common serious neurological condition1. In alloxan in induced diabetic rats the maximum reduction in glucose was observed after 6 hours at a dose level of 200 mgkg of body weight. Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose.
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